1404463-20-2 (2R,3R,4S,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-氟-5-(2-异丁酰胺基-6-氧代-1,6-二氢-9H-嘌呤-9-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺

中文名称: (2R,3R,4S,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-氟-5-(2-异丁酰胺基-6-氧代-1,6-二氢-9H-嘌呤-9-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
英文名称: (2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS号
分子式: C₄₄H₅₃FN₇O₈P
分子量: 857.91
更新日期: 2026-06-23

名称和标识

中文名: (2R,3R,4S,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-氟-5-(2-异丁酰胺基-6-氧代-1,6-二氢-9H-嘌呤-9-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
英文名: (2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS号: 1404463-20-2
分子式: C44H53FN7O8P
分子量: 857.91
中文别名: 2'-F-ANA-dG亚磷酰胺单体; 2'-ARA-2'-F-2'-dG单体(G-FANA单体); 2'-F-2'-ARA-IBU-DG亚磷酰胺单体; 2'-F-2'-ARA-DG(IBU)亚磷酰胺单体; 2'-氟-阿糖DG(IBU)亚磷酰胺单体; N2-异丁酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-氟-2'-脱氧阿糖鸟苷-3'-[2-氰基乙基二异丙基氨基亚磷酸酯]; N2-IBU-5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-氟-2'-脱氧阿糖鸟苷-3'-[2-氰基乙基二异丙基氨基亚磷酸酯]; 2'-F-ANA-DG(IBU)亚磷酰胺单体
英文别名: 2'-F-2'-ara-ibu-dG Phosphoramidite; N-[9-[(2R,3S,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide; 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-CE phosphoramidite; DMT-2'-F-dG(iBu)-ANA-CE Phosphoramidite; 2'-F-2'-ara-N2-ibu-dG phosphoramidite; N2-iBu-5'-O-DMTr-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite; N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; 2'-ara-2'-F-2'-dG Phosphoramidite; 2'-F-dG(iBu)-ANA-CE Phosphoramidite; 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite; N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite; Propanamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; 9-[2-FLUORO-2-DEOXY-5-O-DMTr-B-D-ARABINOFURANOSYL]-N2-ISOBUTYRYL-GUANINE-3-O-CE-AMIDITE

物化属性

LogP: 9.87
XLogP3-AA: 6.1
储存条件: 2-8℃
分子量: 857.9 g/mol
拓扑极性表面积: 171 Å²
溶解度: DMSO: 10 mg/ml; Ethanol: 1-10 mg/ml
精确质量: 857.36772683 Da
酸度系数: 8.68±0.20 (Predicted)

生产及用途

用途与制备

2'-ARA-2'-F-2'-DG单体(G-FANA单体)是一种鸟嘌呤核苷类似物，具有免疫刺激活性，在一些动物模型中可诱导I型干扰素，产生抗病毒作用，研究表明其功能活性依赖于活化Toll样受体7(TLR7)。

医药

词条详情加载中…

1404463-20-2 (2R,3R,4S,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-氟-5-(2-异丁酰胺基-6-氧代-1,6-二氢-9H-嘌呤-9-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺

中文名称

(2R,3R,4S,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-氟-5-(2-异丁酰胺基-6-氧代-1,6-二氢-9H-嘌呤-9-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺

英文名称

(2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

CAS号

分子式

C₄₄H₅₃FN₇O₈P

分子量

857.91

更新日期

2026-06-23