1620813-53-7 H-D-天冬酰胺酰-D-酪氨酰-D-丝氨酰-D-赖氨酰-D-脯氨酰-D-苏氨酰-D-天冬氨酰-D-精氨酰-D-谷氨酰胺酰-D-酪氨酰-D-组氨酰-D-苯丙氨酸

中文名称: H-D-天冬酰胺酰-D-酪氨酰-D-丝氨酰-D-赖氨酰-D-脯氨酰-D-苏氨酰-D-天冬氨酰-D-精氨酰-D-谷氨酰胺酰-D-酪氨酰-D-组氨酰-D-苯丙氨酸
英文名称: (D)-PPA 1
CAS号
分子式: C₇₀H₉₈N₂₀O₂₁
分子量: 1555.65
更新日期: 2026-06-23

名称和标识

中文名: H-D-天冬酰胺酰-D-酪氨酰-D-丝氨酰-D-赖氨酰-D-脯氨酰-D-苏氨酰-D-天冬氨酰-D-精氨酰-D-谷氨酰胺酰-D-酪氨酰-D-组氨酰-D-苯丙氨酸
英文名: (D)-PPA 1
CAS号: 1620813-53-7
分子式: C70H98N20O21
分子量: 1555.65
中文别名: 抑制剂多肽(D)-PPA1; 化合物 (D)-PPA 1
英文别名: D-Asparaginyl-D-tyrosyl-D-seryl-D-lysyl-D-prolyl-D-threonyl-D-α-aspartyl-D-arginyl-D-glutaminyl-D-tyrosyl-D-histidyl-D-phenylalanine; DPPA-1; (R)-3-((2R,3S)-2-((R)-1-(D-asparaginyl-D-tyrosyl-D-seryl-D-lysyl)pyrrolidine-2-carboxamido)-3-hydroxybutanamido)-4-(((R)-1-(((R)-5-amino-1-(((R)-1-(((R)-1-(((R)-1-carboxy-2-phenylethyl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1,5-dioxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-oxobutanoic acid; (3R)-4-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(1R)-1-carboxy-2-phenylethyl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-[[(2R,3S)-2-[[(2R)-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2,4-diamino-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoic acid; D-Phenylalanine, D-asparaginyl-D-tyrosyl-D-seryl-D-lysyl-D-prolyl-D-threonyl-D-α-aspartyl-D-arginyl-D-glutaminyl-D-tyrosyl-D-histidyl-

用途与制备

(D)-PPA 1 是一种抗水解 D 肽拮抗剂，是有效的 PD-1/PD-L1 抑制剂，与 PD-1 结合亲和力为 0.51 μM，体内外均有效。

医药

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