159432-28-7 (D-ALA7)-血管紧张素I/II (1-7)
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安全说明
运输方式:冰袋运输。危险性质:非危险化学品。WGK Germany: WGK 3。海关编码: 2933.29.4300。存储类别: 11 - 可燃固体。
用途与制备
A 779 is a G protein-coupled receptor Mas antagonist (Ang1-7 receptor). In vitro: inhibits Ang-(1-7) effects on PCNA, VSMC proliferation/migration, and inflammatory responses (MCP-1, VCAM-1, IL-1β). In vivo: elevates bone markers (BALP, CTX, TRAcP 5b, OC, DPD) in OVX rats; blocks captopril's bone protective effects and Ang1-7/Mas pathway downregulation.
医药