1332881-26-1 (2-(1H-吲哚-3-基)-1H-咪唑-5-基)(3,4,5-三甲氧基苯基)甲酮

名称和标识

中文名: (2-(1H-吲哚-3-基)-1H-咪唑-5-基)(3,4,5-三甲氧基苯基)甲酮
英文名: (2-(1H-Indol-3-yl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)methanone
CAS号: 1332881-26-1
分子式: C21H19N3O4
分子量: 377.39
中文别名: Sabizabulin
英文别名: Sabizabulin; VERU-111; VERU111; 37L1JX37J5; (2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone; [2-(1H-indol-3-yl)-1H-imidazol-5-yl]-(3,4,5-trimethoxyphenyl)methanone; (2-(1H-indol-3-yl)-1H-imidazol-5-yl)-(3,4,5-trimethoxyphenyl)methanone; Methanone, (2-(1H-indol-3-yl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)-; Methanone, [2-(1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)-; [2-(1H-indol-3-yl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone; RefChem:180746; VERU 111; 889-539-8; ABI-231; APP-111; (2-(1H-indol-3-yl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)methanone; [2-(1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)methanone; SABIZABULIN [INN]; Sabizabulin (USAN/INN); SABIZABULIN [USAN]; sabizabulin(VERU-111)?; SABIZABULIN [WHO-DD]; SCHEMBL724794; UNII-37L1JX37J5; orb1706482; CHEMBL2163631; SCHEMBL20850747; SCHEMBL29359405; SCHEMBL29462511; GTPL11422; WQGVHOVEXMOLOK-UHFFFAOYSA-N; GLXC-15382; GLXC-21333; HDC88126; EX-A14854; AKOS040742814; MS-26139; DB-131242; HY-120599; CS-0078414; S6772; D12519; G17692; T17228; KUM

安全说明

运输方式：冰袋运输。危险描述：非危险化学品，未被GHS分类为危险物质。

用途与制备

作为新型口服α和β管蛋白抑制剂，用于生命科学领域，可阻断管蛋白聚合，非多重耐药机制底物；在体外对卵巢癌细胞系SKOV3和OVCAR3有显著抑制作用，诱导凋亡；体内实验显示抑制肿瘤生长和转移，疗效与紫杉醇相当，耐受性良好。

医药

词条详情加载中…