2033-45-6 3,5-二甲基-4-碘吡唑

危险性质：否

化学合成

化学合成

合成路线 1（1. 合成：2033-45-6）

• 产率：100%
• 合成条件：With ammonium cerium(IV) nitrate; iodine In acetonitrile at 20℃; for 16 h;
• 实验步骤：在250ml反应容器中，将3,5-二甲基-1H-吡唑x51（0.5g，5mmol），I2（0.79g，30mmol）和CAN（1.71g，3mmol）溶于70ml CH3CN中。在室温下搅拌16小时。蒸发溶剂，将残余物溶解在AcOEt中并用10％Na₂S₂O₃水溶液和盐水洗涤。水相用AcOEt再萃取，合并的有机相用Na₂SO₄干燥，过滤并浓缩至干，得到1.15g（100％）粗4-碘-3,5-二甲基-1H-吡唑x52，其不经进一步纯化即用于下一步。LC-MS（MH⁺）：223。
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