化学合成
化学合成
路线1：以2-溴-1-环丙基乙酮（CAS 69267-75-0）和硫脲为原料
- 步骤：将2-溴-1-环丙基乙酮（1g，6.1mmol）和硫脲（0.481g，6.1mmol）溶于15ml甲醇中，回流过夜；蒸发溶剂，得到灰白色固体产物。
- 条件：加热回流
- 产率：100%
- 参考文献：
- [1] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 56
- [2] Patent: US2006/199960, 2006, A1. Location in patent: Page/Page column 25
- [3] Journal of Medicinal Chemistry, 2017, vol. 60, # 8, p. 3352 - 3371
- [4] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2764 - 2778
- [5] Patent: WO2005/110980, 2005, A2. Location in patent: Page/Page column 95
- [6] Patent: WO2014/37480, 2014, A1. Location in patent: Page/Page column 98; 99
- [7] Patent: US2015/31687, 2015, A1. Location in patent: Paragraph 0333; 0334
