72559-06-9 (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-乙酰氧基-6,18,20-三羟基-14-甲氧基-7,9,15,17,19,21,25-七甲基-1′-(2-甲基丙基)螺[9,4-(环氧十五碳烷[1,11,13] trienimino)-2H-呋喃并[2′,3′:7,8]萘并[1,2-d]咪唑-2,4'-哌啶]-5,10,26(3H,9H)-三酮

名称和标识

中文名: (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-乙酰氧基-6,18,20-三羟基-14-甲氧基-7,9,15,17,19,21,25-七甲基-1′-(2-甲基丙基)螺[9,4-(环氧十五碳烷[1,11,13] trienimino)-2H-呋喃并[2′,3′:7,8]萘并[1,2-d]咪唑-2,4'-哌啶]-5,10,26(3H,9H)-三酮
英文名: (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-(Acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1′-(2-methylpropyl)spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3′:7,8]naphth[1,2-d]imidazole-2,4′-piperidine]-5,10,26(3H,9H)-trione
CAS号: 72559-06-9
分子式: C46H62N4O11
分子量: 847
中文别名: Rifabutin
英文别名: Rifabutin; 4-deoxo-3,4-[2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-rifamicin S; Ansamycin; RIFABUTINE; Mycobutin; lm427; Rifabatin; antibioticlm427; 1',4-didehydro-1-desoxi-1,4-di-hydro-5'-(2-methyl-propyl)-1-oxo-rifamycin; Ansatipine; 6,9-dihydro-5,17,19,21-tetrahydroxy-8,9-[2-spiro-(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-23-methoxy-2,4,12,16,18,20,22-heptamethyl-6-oxo-2,7-epoxypentadeca-[1,11,13]-trienimine-2H-furo[2',3',7,8]nafto[1,2-d]imidazolo-2,4'-piperidine-5,10,26. (3H,9H)-trione-16-acetate

安全说明

运输方式：冰袋运输。危险性质：非危险化学品。WGK Germany:3，RTECS号:VJ6700000，海关编码:2941906000，存储类别:11 - 可燃固体，毒害物质数据:72559-06-9

用途与制备

适用于与其他抗结核药联合治疗结核分枝杆菌所致的各型结核病，亦可用于非结核分枝杆菌感染的治疗；本品还适用于晚期HIV感染病人预防MAC的播散；可用于合并HIV患者抗分枝杆菌感染的防治；用于成人治疗幽门螺杆菌（H.pylori）感染（三合一口服胶囊）；对耐药麻风病有效，预防艾滋病人鸟结核分枝杆菌感染。

医药

以1,4-二氢利福霉素S为原料，经溴化，亚硝基取代，氢化，氨化，再和N-异丁基哌啶酮反应，即可得到利福布汀。