3-氨基-5-甲基-6-氯哒嗪是一种有用的研究化学品。
医药研究
合成路线 1（1. 合成：66346-87-0）
产率：43.5%
合成条件：With ammonia In ethanol at 120℃; for 12 h; Heating in a sealed tube
实验步骤：[Linholter，S.，et a /，Acta Chem。SCAND。 15：1660-1666（1961）]。 向3,6-二氯-4-甲基 - 哒嗪（200mg）的乙醇（3ml）溶液中加入液氨（3ml）。 将反应混合物在120℃下在密封管中加热12小时。 冷却至室温后，蒸发甲醇和氨。 通过快速色谱法（乙酸乙酯）纯化残余物，得到153mg 7和10（1：1）的混合物（87％），其无需任何进一步分离即可使用。
参考文献：
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