714971-28-5 (S)-3-(羟甲基)吗啉-4-羧酸叔丁酯

名称和标识

中文名: (S)-3-(羟甲基)吗啉-4-羧酸叔丁酯
英文名: tert-butyl (3S)-3-(hydroxymethyl)morpholine-4-carboxylate
CAS号: 714971-28-5
分子式: C10H19NO4
分子量: 217.26
中文别名: (3S)-3-(羟甲基)吗啉-4-羧酸叔丁酯; (S)-4-BOC-3-吗啉甲醇; 3(S)-羟基甲基-4-boc吗啉; (S)-N-Boc-3-(羟甲基)吗啉; (S)-N-BOC-3-羟甲基吗啉; (3S)-3-(羟甲基)吗啉-4-羧酸叔丁; (S)-4-BOC-(3-羟甲基)吗啉; 3(S)-羟甲基-4-BOC-吗啉
英文别名: (S)-4-Boc-(3-hydroxymethyl)morpholine; 1,1-dimethylethyl (3S)-3-(hydroxymethyl)morpholine-4-carboxylate; 2-Methyl-2-propanyl 3-(hydroxymethyl)-4-morpholinecarboxylate; 3(S)-Hydroxymethyl-4-t-butoxycarbonylmorpholine; (S)-3-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester; 2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-4-morpholinecarboxylate; tert-Butyl-(3S)-3-(hydroxymethyl)morpholin-4-carboxylat; 3-Hydroxymethyl-4-Bocmorpholine; 4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; (S)-tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate; tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate; tert-Butyl-3-(hydroxymethyl)morpholin-4-carboxylat; (S)-4-BOC-3-hydroxymethylmorpholine; (S)-N-Boc-3-hydroxymethylmorpholine; 3(S)-HYDROXYMETHYL-4-BOCMORPHOLINE; (S)-N-BOC-3-(HYDROXYMETHYL)MORPHOLINE; (S)-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester; (S)-4-Boc-3-hydroxymethyl-morpholine; (3S)-3-(Hydroxymethyl)-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester

安全说明

危险性质：非危险化学品

用途与制备

化学合成。

医药; 聚氨酯泡沫生产; 半合成青霉素合成; Lyocell和Newcell人造纤维长丝纺丝

路线1：以(R)-(4-苄基-3-吗啡啉)-甲醇为起始物料

步骤: 向(R)-(4-苄基-3-吗啡啉)-甲醇的二氯甲烷溶液中加入三乙胺，滴加二碳酸二叔丁酯的二氯甲烷溶液，滴毕，反应15小时，减压蒸除溶剂，浓缩物经硅胶柱层析纯化得目标化合物。
条件: 反应溶剂为二氯甲烷，催化剂为三乙胺，反应时间15小时，纯化使用硅胶柱层析，洗脱剂体积比为V(乙酸乙酯)/V(石油醚)=1/10。

词条详情加载中…