81787-62-4 2-((三甲基硅烷基)炔基)苯酚

用于医药相关研究与制备，具体用途需参考相关文献。

医药

合成路线 1（1. 合成：81787-62-4）

产率：87% 合成条件：With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 4 h; Inert atmosphere 实验步骤：通用方法：在氩气氛下，向2-碘代芳烃1（1mmol）的无水THF / Et 3 N（2：1,10mL）溶液中加入Pd（PPh 3）2 Cl 2（0.025mmol）和CuI（0.05mmol）。 然后滴加三甲基甲硅烷基乙炔2（1.3mmol），将得到的混合物在室温下搅拌4小时（TLC）。 减压浓缩反应混合物，残余物用硅胶（100-200目）柱色谱法纯化，用二乙醚石油醚（4-10％）洗脱，得到纯的 - （（三甲基甲硅烷基）乙炔基）芳烃3，产率良好（ 表格1）。 参考文献：

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