1-甲基吡咯烷-2-硫酮主要作为医药中间体或原料，用于相关药物的合成制备。
医药
合成路线 1（1. 合成：10441-57-3）
产率：90%
合成条件：With alumina-supported P 2 S 5 In tetrahydrofuran at 60℃; for 0.08 h; Microwave irradiation; Sealed tube
实验步骤：一般步骤：将苯甲酰胺（0.75mmol）溶解在微波小瓶中的THF（5mL）中，向其中加入P2S5 / Al2O3（0.53g，相当于0.90mmol的P2S5）。然后将小瓶密封，悬浮液为 在CEM Discover。（TM）中在微波辐射下加热。 微波反应器：在60℃下60W，搅拌和空气冷却。 5分钟后完成转化（如TLC所示）。 将整个溶液冷却并倒在短的二氧化硅塞上。 用己烷洗脱该物质以除去非极性杂质，然后用己烷/ EtOAc洗脱以回收产物。 除去溶剂，得到纯的硫代苯甲酰胺，产率为92％。
参考文献：
- [1] Organic Letters, 2012, vol. 14, # 2, p. 440 - 443 [2] Organic Syntheses, 1984, vol. 62, p. 158 - 158 [3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 7, p. 687 - 697 [4] Tetrahedron, 1984, vol. 40, # 11, p. 2047 - 2052 [5] Tetrahedron Letters, 2011, vol. 52, # 40, p. 5131 - 5132 [6] Organic Letters, 2006, vol. 8, # 6, p. 1093 - 1095 [7] Synthetic Communications, 1990, vol. 20, # 19, p. 3085 - 3095 [8] Synthesis, 2006, # 14, p. 2327 - 2334 [9] Journal of Organic Chemistry, 2008, vol. 73, # 7, p. 2890 - 2893 [10] Liebigs Annalen der Chemie, 1992, # 10, p. 1081 - 1086 [11] Helvetica Chimica Acta, 2011, vol. 94, # 5, p. 773 - 784 [12] Helvetica Chimica Acta, 1987, vol. 70, p. 1001 - 1011 [13] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 239 - 245 [14] Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 2, p. 274 - 281 [15] Tetrahedron, 1992, vol. 48, # 10, p. 1953 - 1958 [16] Russian Journal of Organic Chemistry, 2015, vol. 51, # 2, p. 148 - 160 [17] Russian Journal of Organic Chemistry, 2015, vol. 51, # 2, p. 148 - 160,13 [18] Bulletin of the Chemical Society of Japan, 1994, vol. 67, # 8, p. 2219 - 2226 [19] Tetrahedron Letters, 1995, vol. 36, # 45, p. 8311 - 8314 [20] Organic and Biomolecular Chemistry, 2004, vol. 2, # 23, p. 3510 - 3517 [21] Journal of Organic Chemistry, 2006, vol. 71, # 9, p. 3494 - 3500 [22] Synthetic Communications, 1982, vol. 12, # 10, p. 787 - 794 [23] Journal of Organic Chemistry, 2009, vol. 74, # 22, p. 8908 - 8908
