382-44-5 11β-羟基雄甾-4-烯-3,17-二酮

WGK Germany:3 存储类别:11 - 可燃固体

• 生物活性 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。
• 靶点 Human Endogenous Metabolite
• 体外研究 In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
• 体内研究 The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.

医药

体外研究相关合成途径

• 步骤: 在LNCaP细胞系中，通过转染CYP17A1，使21-脱氧皮质醇（21dF）和21-脱氧皮质酮（21dE）分别代谢为11-Beta-hydroxyandrostenedione和11-酮孕酮（11KP4）。
• 条件: 细胞系转染CYP17A1后，检测11-Beta-hydroxyandrostenedione途径代谢物的增加。