体外研究
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
Cell Viability Assay
Cell Line:
Rat liver sinusoidal endothelial cells
Concentration:
2 mM, 5 mM, 10 mM
Incubation Time:
2 hours, 4 hours, 6 hours, 8 hours
Result:
Exhibited cytotoxicity against cultivated endothelial cells.
体内研究
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [
3
H]-acetylcholine release in guinea-pig tracheal.
