用于制备N-(5-(3-叔丁基-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基))-2-甲氧基苯基)-2,3-二氢-1H-茚-1-基)甲磺酰胺等医药化合物。
医药中间体
合成路线 1（1. 合成：34598-50-0）
产率：100%
合成条件：With sodium tetrahydroborate In ethanol at 60℃; for 0.10 h;
实验步骤：将5-溴-2,3-二氢茚-1-酮（47.1）（23.7mmol）和NaBH 4（47.4mmol）在EtOH（50mL）中的混合物在60℃下搅拌6分钟。 蒸发溶剂后，通过色谱（硅胶; 1：2EtOAc /己烷）纯化残余物，得到化合物47.2，收率100％。 MS ESI（pos。）M / E：195.0,197.1（M + H-H 2 O）。
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