3496-11-5 N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯

中文名称: N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯
英文名称: Z-VAL-OSU
CAS号
分子式: C₁₇H₂₀N₂O₆
分子量: 348.35
更新日期: 2026-06-23

名称和标识

中文名: N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯
英文名: Z-VAL-OSU
CAS号: 3496-11-5
分子式: C17H20N2O6
分子量: 348.35
中文别名: N-CBZ-L-缬氨酸琥珀酰亚胺酯; (S)-2,5-二氧代吡咯烷-1-基 2-(((苄氧基)羰基)氨基)-3-甲基丁酸酯; N-CBZ-L-缬氨酸-N-羟基丁二酰亚胺酯; 2,5-二氧代吡咯烷-1-基(苄氧基羰基)-L-缬氨酸
英文别名: Z-VALINE-OSU; Z-L-VALINE HYDROXYSUCCINIMIDE ESTER; Z-L-VALINE N-HYDROXYSUCCINIMIDE ESTER; 2,5-dioxopyrrolidin-1-yl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate; phenyl N-[(3S)-1-(2,5-dioxopyrrolidin-1-yl)-4-methyl-2-oxopentan-3-yl]carbamate; (2,5-dioxopyrrolidin-1-yl) (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate; N-CARBOBENZOXY-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER; Cbz-L-Val-O-succinimide; L-Valine, N-[(phenylmethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester; Z-Val-ONSu; 2,5-Dioxopyrrolidin-1-yl N-[(benzyloxy)carbonyl]-L-valinate; N-Z-L-valine N-hydroxysuccinimide ester; N-Carbobenzoxy-L-valine succinimidyl ester; Benzyl (S)-(1-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-2-methylpropyl)carbamate; N-benzyloxycarbonyl-L-valine succinimide ester; N-Cbz-L-valine Succinimidyl Ester; 2,5-Dioxo-1-pyrrolidinyl N-[(benzyloxy)carbonyl]-L-valinate; N-carbobenzoxy-L-valine N-hydroxysuccinimide ester; Z-Val-OSu

物化属性

LogP: 1.07
储存条件: -15 °C
外观: 白色至类白色粉末
密度: 1.3±0.1 g/cm³
折射率: 1.566
拓扑极性表面积: 102.01000
旋光度: -21.534° (C=0.01 g/ml, 二氧六环)
溶解度: 溶于2mL二氯甲烷，溶解度为1mmol
熔点: 106-120 °C
精确质量: 348.132141
酸度系数: 10.51±0.46 (Predicted)

安全信息

安全说明

海关编码:2933.79.8500

生产及用途

用途与制备

概述 N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯是一种缬氨酸衍生物。

医药

6066-82-6 1149-26-4 3496-11-5 步骤1. 在0°C下，向搅拌的N-羟基丁二酰亚胺（1g，4mmol）和CBZ-L-缬氨酸（459mg，4mmol）的四氢呋喃（THF，20mL）溶液中加入N,N'-二环己基碳二亚胺（DCC，908mg，4.4mmol）。将反应混合物在室温下搅拌16小时。反应完成后，过滤混合物，浓缩滤液，得到(S)-2,5-二氧代吡咯烷-1-基 2-(((苄氧基)羰基)氨基)-3-甲基丁酸酯（产率：90%）。参考文献： [1] Chemical Communications, 2015, vol. 51, # 67, p. 13213 - 13216 [2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 28, p. 7736 - 7749 [3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 133 [4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 989 - 1000 [5] Journal of the American Chemical Society, 2003, vol. 125, # 22, p. 6677 - 6686

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