体内研究
Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an
ED
50
of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol.
Animal Model:
Male CD-COBS rats injected with 1 mg/kg haloperidol
Dosage:
0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg
Administration:
Subcutaneous injection; for 1 hour
Result:
Potently reversed haloperidol-induced catalepsy with an
ED
50
of 0.25 mg/kg.
