化学合成。
化学合成
合成路线 1(1. 合成:159326-69-9)
产率:87%
合成条件:With potassium hydroxide; dihydrogen peroxide In water at 20℃;
实验步骤:将1-氨基-1H-吡咯-2-甲腈(2.52g,23.5mmol)悬浮在75ml水中,用氢氧化钾(32g,0.57mol),30%过氧化氢(2ml)处理并在室温下搅拌过夜。。 将反应混合物冷却至0℃30分钟,过滤分离产物,用冷水洗涤并真空干燥,得到2.55g产物(产率:87%)
参考文献:
- [1] Patent: WO2006/35061, 2006, A1. Location in patent: Page/Page column 50; 51 [2] Patent: WO2016/190847, 2016, A1. Location in patent: Paragraph 0341 [3] Patent: CN104974163, 2017, B. Location in patent: Paragraph 0514; 0515; 0516; 0517 [4] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 4, p. 781 - 786 [5] Patent: CN104876935, 2017, B. Location in patent: Paragraph 0066; 0069; 0070 [6] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1429 - 1440 [7] Journal of Medicinal Chemistry, 2004, vol. 47, # 16, p. 4054 - 4059 [8] Patent: WO2010/2472, 2010, A1. Location in patent: Page/Page column 88-89 [9] Patent: CN106432249, 2017, A. Location in patent: Paragraph 0030; 0031; 0034; 0035; 0038; 0039; 0042; 0043 [10] Patent: CN104003990, 2017, B. Location in patent: Paragraph 0131; 0135; 0136 [11] Patent: WO2009/117157, 2009, A1. Location in patent: Page/Page column 47