35264-09-6 1-((叔丁氧羰基)氨基)环戊烷羧酸

危险性质：非危险化学品 危险品属性：非危险品

生命科学。

医药; 有机合成

合成路线 1（1. 合成：35264-09-6）

产率：73% 合成条件：Stage #1: With sodium hydroxide; triethylamine In water; acetonitrile at 0 - 20℃; for 4 h; Stage #2: With water In ethyl acetate Stage #3: With hydrogenchloride In water 实验步骤：向250mL圆底烧瓶中加入环亮氨酸（1.0g，7 [74MMOL]，] [ET3N]（5.4mL，38 [7MMOL]] 1M NaOH（7.74mL，7。[74MMOL]]和[CH3CN] ]（10mL）。 将澄清溶液冷却至[0℃]并向其中加入[（BOC）] [2O]。将反应温热至室温并搅拌4小时，在此期间形成白色沉淀。 浓缩反应混合物，将残余物溶于EtOAc：水（1：1）[（100ML）]中。有机相用水洗涤，合并水相，用10％HCl处理，然后用EtOAc萃取三次。倍。 将合并的有机相依次用水，盐水洗涤，用[MGSO 4]干燥，过滤并浓缩，得到标题化合物，为白色固体（1.29g，73％）。 参考文献：

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