化学合成；生命科学。
化学合成；生命科学
合成路线 1（1. 合成：115962-35-1）
产率：100%
合成条件：With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 144 h;
实验步骤：将（S）-1,2,3,4-四氢异喹啉-3-羧酸（50.0g，282mmol）在1,4-二恶烷（1000mL）和水（500mL）的混合物中剧烈搅拌。 加入碳酸氢钠（47.4g，564mmol）和Boc酐（67.7g，310mmol），将反应混合物在室温剧烈搅拌6天。 将混合物真空浓缩，将残余物溶于水（2000mL）中。 加入30％w / v的硫酸氢钠一水合物水溶液（300mL），用氯仿（3×1000mL）萃取混合物。 将合并的有机萃取液用盐水洗涤，用硫酸钠干燥并真空浓缩，得到所需化合物（90.0g，定量），为稠浆状物。 LCMS-B：RT 3.64分钟; m / z 178.1 [M-Boc + 2H] +; m / z 276.1 [M-H] -
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