59281-14-0 5-(苄氧基)-2-(羟甲基)吡啶-4(1H)-酮

中文名称: 5-(苄氧基)-2-(羟甲基)吡啶-4(1H)-酮
英文名称: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
CAS号
分子式: C₁₃H₁₃NO₃
分子量: 231.25
更新日期: 2026-06-23

名称和标识

中文名: 5-(苄氧基)-2-(羟甲基)吡啶-4(1H)-酮
英文名: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
CAS号: 59281-14-0
分子式: C13H13NO3
分子量: 231.25
英文别名: 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol; 2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-Pyridinone; 2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine; 4(1H)-Pyridinone, 2-(hydroxymethyl)-5-(phenylmethoxy)-; 5-benzyloxy-4-hydroxy-2-hydroxymethylpyridine

词条详情加载中…

生产及用途

用途与制备

用于医药领域相关研究（如药物合成或生物活性研究）

医药

合成路线 1（1. 合成：59281-14-0）

产率：80% 合成条件：at 70℃; for 18 h; 实验步骤：5-（苄氧基）-2-（羟基甲基）-4H-吡喃-4-酮（53.2g，229mmol）在IMS（75ml）和水溶液中的悬浮液。将NH 4 OH溶液（400ml）在70℃下搅拌18小时。将冷却的溶液用水（400ml）稀释，冷却至室温并将悬浮液搅拌30分钟。将固体过滤并真空干燥，得到标题化合物10，为浅棕色固体（42.5g，80％收率）。 LC-MS（M-H +）= 232.1HNMR（300MHz，DMSO-d6）：o 11.08（br s，1H），7.51-7.28（m，6H），6.16（br s，1H）， 5.56（br s，1H），5.01（s，2H），4.34（s，2H）。 参考文献：

[1] Dalton Transactions, 2016, vol. 45, # 15, p. 6517 - 6528 [2] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684 [3] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 150 [4] Patent: CN106986819, 2017, A. Location in patent: Paragraph 0024-0026; 0028-0030 [5] Patent: CN106986820, 2017, A. Location in patent: Paragraph 0031-0032 [6] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3103 - 3108 [7] Patent: WO2007/118130, 2007, A2. Location in patent: Page/Page column 32-33 [8] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5038 - 5040 [9] Australian Journal of Chemistry, 1983, vol. 36, # 11, p. 2307 - 2316 [10] Patent: WO2006/81264, 2006, A1. Location in patent: Page/Page column 26 [11] Patent: WO2006/81182, 2006, A2. Location in patent: Page/Page column 24 [12] Patent: US4632985, 1986, A [13] Patent: US4743685, 1988, A [14] Patent: US4743685, 1988, A [15] Patent: WO2004/2490, 2004, A2. Location in patent: Page/Page column 54 [16] Patent: WO2004/2992, 2004, A1. Location in patent: Page 89 [17] Patent: WO2006/2047, 2006, A2. Location in patent: Page/Page column 94 [18] Patent: WO2006/17326, 2006, A1. Location in patent: Page/Page column 26 [19] Patent: WO2006/21448, 2006, A1. Location in patent: Page/Page column 69-70 [20] Patent: WO2006/20561, 2006, A2. Location in patent: Page/Page column 35 [21] Patent: WO2007/16610, 2007, A2. Location in patent: Page/Page column 37 [22] Patent: US2010/324030, 2010, A1. Location in patent: Page/Page column 12 [23] Patent: WO2014/57415, 2014, A2. Location in patent: Page/Page column 17 [24] Medicinal Chemistry Research, 2015, vol. 24, # 12, p. 4113 - 4127