化学合成。
医药; 化工
合成路线 1（1. 合成：885518-82-1）
产率：93.3%
合成条件：With iodine; potassium hydroxide In N,N-dimethyl-formamide at 0 - 20℃; for 1 h;
实验步骤：在0℃下向26-S1（2.5g，14.2mmol）的DMF（30mL）溶液中分批加入KOH（1.8g，31.9mmol，然后分别加入碘（5.4g，21.3mmol）。反应混合物为 在室温下搅拌1小时。将反应混合物倒入冰水中，用EtOAc萃取两次。合并的有机物用5％Na 2 S 2 O 4水溶液和盐水洗涤，干燥，浓缩至干，得到26-S2（4.0g， 得到93.3％产率，为黄色固体，其不经进一步纯化直接在下一合成步骤中进行.LC / MS（ESI）m / z：303（M + H）+。
参考文献：
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