1-苯基-1氢-4-甲醇基-1,2,3-三唑作为含三唑环的有机中间体，广泛应用于医药和农药领域，其衍生物具有生物活性。
医药; 农药
合成路线 1（1. 合成：103755-58-4）
产率：95%
合成条件：With copper(ll) sulfate pentahydrate; hydrazine hydrate In water; acetonitrile at 20℃; for 0.67 h;
实验步骤：通用方法：在室温下将叠氮化物（1当量），炔烃（1.5当量）和CuSO 4·5H 2 O（0.1当量）溶于水和乙腈（12mL; 2：1，v / v）的混合物中。 在剧烈搅拌下将水合肼（1当量）滴加到上述溶液中。 反应物质变为浅黄色或浅绿色。 几分钟后（参见表3确切的反应时间），TLC显示反应完成。 通常产物沉淀为无色固体（除非另有说明）。 用过量的水稀释反应混合物并过滤。 将沉淀的产物用水洗涤并干燥。 这样得到的固体在溶解在适当的溶剂中后可以结晶或通过小硅藻土垫得到分析纯的产物。
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