化学合成。
化学合成
合成路线 1（1. 合成：39885-08-0）
产率：95%
合成条件：With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
实验步骤：将50.0g（286mmol）2-氨基-6-氯苯基酸溶于300ml无水THF（四氢呋喃）（2-氨基-6-氯苯甲酸）混合物中，将溶液冷却至0~10℃，加入450ml 1.0M 氢化铝锂THF溶液，将反应混合物温热至室温，然后在室温下搅拌过夜。向反应混合物中加入300ml 10％NaOH水溶液。分离有机相并用乙酸乙酯和水洗涤。。 用硫酸镁干燥后，真空除去溶剂，得到42g（270mmol，95％）黄色固体产物。无需进一步纯化。
参考文献：
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