- 2-(2-BOC-氨基乙氧基)乙醇可用作医药合成中间体
- 危险处理
如果吸入2-(2-BOC-氨基乙氧基)乙醇，请将患者移到新鲜空气处；如果皮肤接触，应脱去污染的衣着，用肥皂水和清水彻底冲洗皮肤，如有不适感，就医；如果眼晴接触，应分开眼睑，用流动清水或生理盐水冲洗，并立即就医；如果食入，立即漱口，禁止催吐，应立即就医。
医药
合成路线 1（1. 合成：139115-91-6）
产率：100%
合成条件：at 20℃;
实验步骤：化合物100的制备：在室温下，向2-（2-氨基乙氧基）乙醇（2.10g，20mmol）的CH 2 Cl 2（40mL）溶液中加入二碳酸二叔丁酯（4.36g，20mmol）。 通过TLC监测反应。 当反应完成时，浓缩内容物并通过柱色谱法（50-70％EtOAc /己烷）纯化，得到化合物100，为无色油状物（4.21g，100％）。 分析型TLC（硅胶60），80％EtOAc的正己烷溶液，Rf = 0.30; NMR（400MHz，CDCl 3）δ5.28（br s，1H），3.74（br t，/ = 4.1Hz，2H），3.59-3.54（m，4H），3.32-3.28（m，2H），3.08（br s，1H），1.44（s，9H）; 13 C NMR（100MHz，CDCl 3）δ156.1,79.2,72.2,70.2,61.5,40.3,28.3; IR（CH 2 Cl 2）3228（br），3035,2927,2855,1523cm -1; LRMS（ESI）m / z 228.0（M + + Na）; HRMS（ESI）计算值C 9 H 20 NO 4（M + + H）m / m z 206.1392，发现206.1390。
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