147252-84-4 (1-羟基丙烷-2-基)氨基甲酸叔丁酯

危险性质：非危险化学品

多肽合成，氨基酸保护单体。

医药

合成路线 1（1. 合成：147252-84-4）

产率：94% 合成条件：With triethylamine In tetrahydrofuran at 0 - 20℃; for 18 h; 实验步骤：将10克（133毫摩尔）（R）-2-氨基-1-丙醇和14.8克（146.5毫摩尔）三乙胺在500毫升四氢呋喃中的溶液冷却至0℃。向该溶液中一次性加入30克（ 133mMol）二碳酸二叔丁酯。 将反应混合物在室温下搅拌约18小时。 然后将反应混合物减压浓缩，将得到的残余物溶于300mL乙酸乙酯中。 将该溶液用200mL水洗涤两次，用200mL饱和氯化钠水溶液洗涤一次，用硫酸镁干燥并减压浓缩，得到22g（94％）所需化合物，为黄色油状物.1H-NMR（ CDCl3）：δ4.71（m，1H），3.72（m，1H），3.59-3.46（m，2H），2.86（m，1H）。 参考文献：

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