化学合成。
化学合成
合成路线 1(1. 合成:20348-16-7)
产率:98%
合成条件:With hydrogen In ethanol at 50℃; for 1 h;
实验步骤:将3-羟基-6-甲基-2-硝基吡啶(30g,194.6mmol)在50℃的乙醇溶液中使用H 2在5psi和20%Pd(OH)2 / C催化剂下氢化1小时。 反应完成后,滤除催化剂,减压浓缩滤液,得到所需产物1,为棕色固体(23.68g,98%)。 NMR数据与提出的结构一致。
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