169105-89-9 (3R,4R,5R)-5-(羟甲基)哌啶-3,4-二醇

名称和标识

中文名: (3R,4R,5R)-5-(羟甲基)哌啶-3,4-二醇
英文名: (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
CAS号: 169105-89-9
分子式: C6H13NO3
分子量: 147.17
中文别名: (3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇; 异桑叶生物碱; 阿戈司他; 异法戈明; D-异法戈明
英文别名: Isofagomine; Afegostat; D-Isofagomine; 5-(Hydroxymethyl)piperidine-3,4-diol; IFM; 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE; iso-Fagomine

用途与制备

生物活性 Afegostat 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。
靶点 GCase
体内研究 Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.

医药

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