化学合成。
化学合成
合成路线 1（1. 合成：134615-22-8）
产率：97%
合成条件：With trans-[OsCl 2 (py){2,6-bis[4’-(S)-isopropyloxazolin-2-yl]pyridine}]; caesium carbonate In isopropyl alcohol at 82℃; for 4 h; Inert atmosphere; Schlenk technique
实验步骤：一般步骤：将催化剂[0.4mol％（配合物12-22）或0.2mol％（双核配合物24）]和酮（2.5mmol）置于干燥氩气氛下的三底Schlenk烧瓶和2-丙醇（45mL）中 ） 加入。 在82℃下搅拌混合物15分钟后，加入5ml 0.06M的2-丙醇（0.3mmol）中的碱（Cs 2 CO 3）溶液。 使用HP-6890设备通过气相色谱监测反应。 在所有情况下检测到相应的醇和酮是唯一的产物。 通过GC用Supelcoβ-DEX 120手性毛细管柱测定转化率和e.e.值。
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合成路线 2（2. 合成：134615-22-8）
产率：89%
合成条件：Stage #1: With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); water In methanol at 110℃; for 6 h; Stage #2: With C 26 H 26 ClN 2 O 2 RhS; water; sodium formate In methanol at 30℃; for 5 h;
实验步骤：将3-溴苯乙炔（1mmol），[（IPr）AuCl]（6.2mg，1mol％），甲醇（1ml）和水（0.5ml）的溶液依次加入25ml Schlenk反应烧瓶中。 将混合物在110℃反应6小时，然后冷却至室温。[Cp * RhCl [（R，R）-TsDPEN]（1.7mg，0.003mmol），水（1.5ml）和甲酸钠（340mg） ，5当量。）加入反应烧瓶中。 将混合物在30℃下进一步反应5小时，然后冷却至室温。 通过旋转蒸发除去溶剂，然后通过柱色谱（展开溶剂：乙酸乙酯/石油醚）获得标题化合物，收率为89％，e.e.percent = 89％
参考文献：
- [1] Patent: CN106032347, 2016, A. Location in patent: Paragraph 0058-0060 [2] Journal of Organic Chemistry, 2015, vol. 80, # 7, p. 3538 - 3546
