2373-89-9 4,4'-二甲氧基查耳酮

名称和标识

中文名: 4,4'-二甲氧基查耳酮
英文名: 4,4'-DIMETHOXYCHALCONE
CAS号: 2373-89-9
分子式: C17H16O3
分子量: 268.31
中文别名: 4,4'-甲氧基查耳酮; 1,3-双(4-甲氧基苯基)丙-2-烯-1-酮; 4,4'-二甲氧基查尔酮
英文别名: 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE; 2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-; 4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE; 4,4'-Dimethoxychalcone; (E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE

安全说明

海关编码:29145090

用途与制备

生物活性 4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。
靶点 Autophagy
体内研究 The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species. 4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice. Animal Model: 6-week-old male wild type C57BL/6 or Atg4b -/- mice Dosage: 100 mg/kg Administration: Injected intraperitoneally with a single Result: Triggered autophagic flux in the heart and liver.

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