化学合成。
化学合成
合成路线 1（1. 合成：33577-99-0）
产率：96%
合成条件：With cesium fluoride In water; acetonitrile at 20℃; for 4 h;
实验步骤：准备28; 2-乙炔基 - 苯甲酸甲酯; 向2-三甲基硅烷基乙炔基 - 苯甲酸甲酯（540mg，2.32mmol）的乙腈/水（20mL / 5mL）溶液中加入氟化铯（1.41g，9.30mmol）。 将反应在室温下搅拌。 4小时后，浓缩反应物，将残余物在EtOAc（100mL）和0.2N HCl（30mL）之间分配。 将水层用EtOAc（100mL）萃取，并将合并的有机层用盐水洗涤，干燥（MgSO 4），过滤并浓缩。 将残余物进行色谱分离，用0至5％EtOAc /己烷洗脱，得到标题化合物（358mg，96％）。 GC / MS：160。
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