71160-24-2 白三烯B4

危险品运输编号:UN 1170 3/PG 2 WGK Germany:1 存储类别:3- 易燃液体 危险性类别:眼部刺激 类别2 易燃液体 类别2

• 生物活性 Leukotriene B4 (LTB4) 是白细胞最有效的化学诱导剂和激活剂之一，参与多种炎症性疾病。Leukotriene B4 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。
• 靶点 Alkyl-Chain Human Endogenous Metabolite
• 体外研究 Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation. Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid.

医药

合成路线：在髓系细胞中，以花生四烯酸为起始原料，通过特定酶促反应（具体酶未明确）合成Leukotriene B4。