作为医药合成中间体，用于有机合成反应中保护氨基基团。
医药
合成路线 1（1. 合成：137618-48-5）
产率：100%
合成条件：With sodium hydroxide In tert -butyl alcohol at 0 - 20℃; for 5 h;
实验步骤：将3g（1.0当量，32.93mmol）3-氨基-1,2-丙二醇23溶于20mL叔丁醇和20mL 1M NaOH中，并在冰冷却下，加入20mL叔丁醇溶液含有7.19克（1.0当量，32.93毫摩尔）Boc2O。之后，在室温下搅拌5小时。通过TLC确认反应物质消失后，使用蒸发器在50℃的水浴中减压浓缩。然后，使用1M HCl中和反应溶液。通过加入乙酸乙酯和水进行中和溶液的液体分馏萃取3次，并将收集的有机层用饱和NaCl水溶液洗涤。用硫酸镁干燥后，使用蒸发器在40℃的水浴中减压浓缩。结果，得到6.3g所需化合物2（产率：定量）。 1H-NMR信号分配如下：1 H-NMR（500MHz，CDCl3）δ1.45（9H，s），2.68-2.71（1H，br），2.75-2.81（1H，br），3.20（2H） ，dd），3.63（2H，dd），3.71（1H，m）4.91（1H，br）。
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