作为医药中间体，用于相关药物分子的合成。
医药中间体
合成路线 1（1. 合成：95656-86-3）
产率：100%
合成条件：With N-ethyl-N,N-diisopropylamine In methanol at 20℃;
实验步骤：步骤1：向1-氨基 - 丙-2-醇（化合物42.1; 3.53g，47.0mmol）和TEA（25mL）的MeOH（35mL）混合物中缓慢加入二碳酸二叔丁酯溶液 （10.3g，47.0mmol）的MeOH（15mL）溶液。 将所得溶液在室温下搅拌过夜。 然后浓缩混合物，残余物在高真空下干燥，得到8.23g（定量）透明油状物。 将由此获得的油状物溶于THF（100mL）中并用TEA（13.1mL，94.0mmol）处理。 在氮气下，在0℃下向所得溶液中滴加甲磺酰氯（0.3.82mL，49.3mmol）。 1小时后，将混合物用EtOAc稀释，并用1M HCl水溶液，碳酸氢钠水溶液和盐水洗涤。 将有机相干燥（Na 2 SO 4）并浓缩，得到10.5g（88％）透明油状的（化合物42.2），其在静置时固化，ES（+）MS m / e = 254（M + H +）。
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