化学合成。
化学合成
合成路线 1（1. 合成：955959-84-9）
产率：93%
合成条件：With tetrakis(triphenylphosphine) palladium (0) ; potassium carbonate In tetrahydrofuran; water at 80℃; for 8 h; Inert atmosphere
实验步骤：在氮气氛下，将二苯并呋喃-4-基硼酸（100g，472mmol）溶于1,000mL四氢呋喃（THF）1-溴-4-碘苯（160g，556mmol）和四（三苯基膦）钯（5.45）中。 向其中加入g，4.72mmol）并搅拌。加入用水饱和的碳酸钾（78.3g，566mmol），并将混合物在80℃下加热回流8小时。 反应完成后，将水加入到反应混合物中，并将混合物用二氯甲烷（DCM）萃取。 然后，用无水MgSO 4除去水，过滤并减压浓缩。通过快速柱色谱法纯化由此获得的残余物，得到化合物I-9（142g，93％）。
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