化学合成。
医药中间体；化学合成
合成路线 1（1. 合成：17639-64-4）
产率：99%
合成条件：With NaH In tetrahydrofuran; water
实验步骤：实施例6向60％NaH（3.13g）的THF（20mL）悬浮液中滴加吡咯（5.00g）的THF（20mL）溶液。 将混合物搅拌30分钟，向其中加入对甲苯磺酰氯（14.2g）的THF（20mL）溶液，并将混合物在室温下搅拌3小时。 将水加入到反应溶液中，分离有机层，干燥，过滤并浓缩。 将残余物从甲醇和水的混合溶剂（各35mL）中重结晶，过滤收集所得晶体，干燥，得到1-对甲苯磺酰基-1H-吡咯（16.3g，99％）。 1H NMR（CDCl3,300MHz）δ7.73（dt，2H，J = 8.4和2.0Hz），7.27（dt，2H，J = 8.4和2.0Hz），7.15（dd，2H，J = 2.2和2.4Hz） ，6.28（dd，2H，J = 2.2和2.4Hz），2.40（s，3H）。
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