4-溴-3-(溴甲基)苯甲酸甲酯主要用于医药和农药领域,具体用途未在输入数据中详细说明。
医药; 农药
合成路线 1(1. 合成:142031-67-2)
产率:77%
合成条件:With N-Bromosuccinimide In dichloromethane; water for 10 h; Heating / reflux; Irradiation
实验步骤:步骤1:; 制备4-溴-3-溴甲基苯甲酸甲酯在装有冷凝器,中央机械搅拌器和温度计的6升反应器中,引入575g(2.5mol)4-溴-3-甲基苯甲酸甲酯,3升亚甲基 氯化物,494g(2.75mol)N-溴代琥珀酰亚胺和17g过氧化苯甲酰(0.05mol; 70%水溶液)。 在用1000瓦灯照射下将混合物加热回流10小时。 用1升水洗涤混合物两次,然后用1升饱和氯化钠溶液洗涤。 蒸发二氯甲烷。 重结晶从庚烷获得的粗产物。 得到596g灰白色晶体形式的4-溴-3-溴甲基苯甲酸甲酯(产率= 77%)。熔点:100-101℃.1H NMR(CDCl3; 400MHz):3.94(s; 3H); 4.64(s:2H); 7.68(d; 1H; Jo = 8.3 Hz); 7.83(d.x.d; 1H; Jo = 8.3 Hz,Jm = 2.0 Hz); 8.14(d; 1H; Jm = 2.0 Hz)
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