1-氰基-环丙基羧酸乙酯是有机合成中间体和医药中间体，可用于实验室研发中有机合成过程和化工医药合成过程中。
有机合成; 医药
合成路线 1（1. 合成：1558-81-2）
产率：72%
合成条件：With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 80℃;
实验步骤：将氰基 - 乙酸乙酯（11.3g，0.1mol），1,2-二溴乙烷，Na 4（n-Bu）4Br和K 2 CO 3在DMF（100mL）中的悬浮液加热至80℃过夜。 将混合物倒入水（600mL）中并用EtOAc（3×50mL）萃取。 将合并的有机层用盐水洗涤，用Na 2 SO 4干燥，在减压下浓缩，得到粗产物，将其通过硅胶柱色谱纯化（石油醚：EtOAc = 10：15：1），得到1-氰基 - 环丙烷羧酸乙酯（10g，收率：72％）。 1H NMR（CDCl3 400MHz）：δ4.21（q，J = 7.2Hz，2H），1.65-1.61（m，2H），1.58-1.55（m，2H），1.28（t，J = 7.2Hz，3H））
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