115010-11-2 2,3-二氢苯并呋喃-5-磺酰氯

危险性质：非危险化学品

医药中间体。

医药

合成路线 1（1. 合成：115010-11-2）

产率：100% 合成条件：Stage #1: With sulfur trioxide-N,N-dimethylformamide complex In 1,2-dichloro-ethane at 85℃; for 1 h; Stage #2: With thionyl chloride In 1,2-dichloro-ethane at 20 - 75℃; for 1 h; 实验步骤：在氩气下，将3.56g（29.6mmol）2,3-二氢苯并呋喃加入到5.44g（35.5mmol）三氧化硫-N，N-二甲基甲酰胺络合物在12mL 1,2-二氯乙烷中的浆液中。 将反应加热至85℃保持1小时，然后冷却至室温。 逐滴加入亚硫酰氯（2.6mL，35.5mmol，1.2当量）并在1小时内缓慢加热反应，此时它已达到75℃。将混合物冷却至室温并且100mL 加入二氯甲烷和100毫升水。 分离有机萃取物，用硫酸镁干燥，过滤并蒸发，得到6.56g（100％）2,3-二氢苯并呋喃-5-磺酰氯，为棕褐色油状物。 （TLC Rf氯仿/己烷= 1/1） 参考文献：

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