化学合成。
化学合成
合成路线 1（1. 合成：404827-77-6）
产率：85.7%
合成条件：With hydrazine hydrate In butan-1-ol for 4 h; Inert atmosphere; Reflux
实验步骤：在氮保护下，将4-溴-2-氟苄腈（5g，25.13mmol）溶解在20mL正丁醇中，加入水合肼（1.04mL，50.26mmol），加热回流4小时。 冷却至室温后，沉淀出大量固体。用抽吸和石油醚洗涤滤饼，干燥，得到4.759g白色固体，收率85.7％。
参考文献：
- [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4579 - 4584 [2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 6, p. 1985 - 1989 [3] Patent: CN106032359, 2016, A. Location in patent: Paragraph 0044; 0045; 0046 [4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 747 - 757 [5] Patent: CN106146493, 2016, A. Location in patent: Paragraph 0452; 0453; 0454; 0455 [6] Patent: WO2016/96709, 2016, A1. Location in patent: Page/Page column 51; 52 [7] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569 [8] Patent: US2006/106083, 2006, A1. Location in patent: Page/Page column 23 [9] Patent: US2007/161626, 2007, A1. Location in patent: Page/Page column 8 [10] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 1, p. 279 - 282 [11] Patent: US2004/14802, 2004, A1. Location in patent: Page/Page column 17 [12] Patent: WO2011/115725, 2011, A2. Location in patent: Page/Page column 51 [13] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3782 - 3786 [14] Advanced Synthesis and Catalysis, 2018, vol. 360, # 10, p. 1943 - 1948
