化学合成。
化学合成
合成路线 1（1. 合成：66607-27-0）
产率：100%
合成条件：Stage #1: With sodium hydroxide; iodine In methanol; water at 20℃; for 73 h; Stage #2: With hydrogenchloride; sodium thiosulfate In methanol; water at 0℃;
实验步骤：在1小时内将58.1g碘（229mmol）分批加入到25.6g吲唑（217mmol）在625ml甲醇和625ml 2N氢氧化钠溶液中的悬浮液中。 将混合物在室温下搅拌3天，然后加入75ml浓盐酸，同时用冰冷却，用2N盐酸使混合物酸化，加入20％浓度的硫代硫酸钠五水合物溶液直至碘颜色消失。 抽出分离出的沉淀物，用水洗涤中性，在50℃的真空干燥箱中干燥。为了纯化，将固体溶于甲醇中。 滤除未溶解的成分后，将滤液在旋转蒸发器上浓缩至干，得到的产物几乎为白色固体。产量：52.6g（定量）Rf值：0.63（硅胶;环己烷/乙酸乙酯1：1） ）熔点：137℃
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