用于医药、农药等领域的合成中间体或原料。
医药; 农药
合成路线 1（1. 合成：67751-23-9）
产率：91%
合成条件：at 110℃; for 3 h;
实验步骤：加入1,1-二甲氧基-N，N-二甲基甲胺（100g，839mmol，1.02当量）和1,1-二甲氧基丙烷-2-酮（97g，821mmol）并在110℃下搅拌3小时。 小时。 通过Dean-Stark装置除去生成的甲醇。 将溶液冷却至室温后，真空除去剩余的挥发性物质，得到130g粗产物，（E）-4-（二甲基氨基）-1,1-二甲氧基丁-3-烯-2-酮（ 1）（130克，理论值143克，91％）。 LC-MS m / z 283（M + 1）。 参考文献：WO 2006 / 0097341A1（通过引用并入），第67页。
参考文献：
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