化学合成。
化学合成
合成路线 1（1. 合成：13336-31-7）
产率：96%
合成条件：With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3 h;
实验步骤：将4-羟基 - 茚满-1-酮（125mg），K 2 CO 3（350mg），甲基碘（263μL）在DMF（4mL）中的混合物在50℃下搅拌3小时，然后倒入1N中。 加入盐酸（20mL）并用Et 2 O（4.×10mL）洗涤。 将合并的有机层用MgSO 4干燥，过滤并浓缩，得到中间体，为透明油状物（131mg; 96％）。[MH] + =163。
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