化学合成。
化学合成
合成路线 1（1. 合成：103935-47-3）
产率：93.33%
合成条件：Stage #1: With pyridine In dichloromethane at -20℃; for 0.50 h; Inert atmosphere; Large scale Stage #2: at 0℃; for 1 h; Inert atmosphere; Large scale
实验步骤：在N 2保护下，将吡啶（1.74Kg，22.01mol，1.10当量）在二氯甲烷（20L）中的溶液冷却至-20℃，缓慢滴加三氟甲磺酸酐（5.87Kg，20.81mol，1.04当量）。 将反应体系在-20℃下搅拌0.5小时，缓慢滴加2-溴乙醇（2.50Kg，20.01摩尔，1.0当量）。将反应温度保持在0℃以下，搅拌1.0小时。 TLC（石油醚：乙酸乙酯= 5：1）显示反应完成。 反应完成后，过滤反应体系，浓缩滤液，加入石油醚（15L），过滤沉淀的固体，浓缩滤液，得到化合物b。 （4.80Kg，产率93.33％）是深黄色油
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