化学合成。
化学合成
合成路线 1（1. 合成：367-80-6）
产率：95%
合成条件：for 15 h; Heating / reflux
实验步骤：步骤1：4-氟-3-硝基 - 苯甲酸乙酯将5.00g（27.0mmol）4-氟-3-硝基 - 苯甲酸在50mL饱和的乙醇盐酸溶液（1.25M）中回流15小时。 使用旋转蒸发仪蒸发反应混合物，并通过快速柱色谱[硅胶，石油醚/乙酸乙酯（4/1）]纯化。 得到5.48g（25.7mmol，95％）4-氟-3-硝基 - 苯甲酸乙酯，为无色固体。 Rf = 0.48 [硅胶，石油醚/乙酸乙酯（4/1）] MS [ESI（M + H）+] = 214
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