- 化学性质
2-氨基异丁酸甲酯盐酸盐可在中强碱性物质的作用下发生酸碱中和反应得到相应的活性氨基羧酸酯类。
- 2-氨基异丁酸甲酯盐酸盐主要用作有机合成中间体和医药分子基础化学原料,在氨基酸类功能有机分子的制备领域中有较好的应用。
有机合成中间体;医药分子基础化学原料
合成路线 1(1. 合成:15028-41-8)
产率:98%
合成条件:at 20℃; for 3 h; Cooling with ice
实验步骤:加入2-氨基-2-甲基丙酸(10g,96.9mmol)和甲醇(330ml)。 设置冰浴,向其中缓慢加入亚硫酰氯(17.68ml,242.25mmol)。 然后,移去冰浴,将混合物在室温下搅拌3小时。 真空蒸馏所得产物以除去溶剂,并在60℃烘箱中干燥,以获得2-氨基-2-甲基丙酸甲酯盐酸盐(14.59g,94.9mmol,98%)。[938] 1H NMR(400MHz,DMSO-d6)8.75(br,3H),3.75(s,3H),1.45(s,6H)。
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