化学合成。
医药; 化工
合成路线 1（1. 合成：170487-40-8）
产率：83%
合成条件：With acetic acid; sodium nitrite In water at 20℃; for 5 h; Acidic aqueous solution
实验步骤：向3-氨基-4-甲基 - 苯甲酸甲酯（15g，90.9mmol）的HOAc（400mL）混合物中逐滴加入NaNO 2（6.27g，90.9mmol）的H 2 O（90mL）溶液。 将混合物在环境温度下搅拌5小时。 然后真空浓缩。 将得到的固体用乙酸乙酯（400mL）研磨并过滤。 浓缩滤液，得到标题化合物（13.3g，83％）。 m / z（M + H）= 177.18
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