2-溴-4-甲氧基苯酚是重要的有机合成中间体,广泛应用于医药和农药领域,具体用途需结合下游合成反应确定。
医药; 农药
合成路线 1(1. 合成:17332-11-5)
产率:100%
合成条件:With bromine In chloroform at 0 - 20℃; for 2 h;
实验步骤:在0℃下,向4-甲氧基苯酚(10g,81mmol)的CHCl 3(50mL)溶液中加入BR(4mL,78mmol)。 将混合物在0℃下搅拌1小时,然后温热至室温,将混合物在室温下搅拌1小时。 将得到的混合物用二氯甲烷(500mL)稀释,用饱和NaHSO 3(3×100mL)和盐水(200mL)洗涤,用无水硫酸钠干燥,过滤并浓缩,得到标题化合物(16.6g,100%),为 灰白色固体,用于下一步。
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