2-溴-4-甲氧基苯酚是重要的有机合成中间体，广泛应用于医药和农药领域，具体用途需结合下游合成反应确定。
医药; 农药
合成路线 1（1. 合成：17332-11-5）
产率：100%
合成条件：With bromine In chloroform at 0 - 20℃; for 2 h;
实验步骤：在0℃下，向4-甲氧基苯酚（10g，81mmol）的CHCl 3（50mL）溶液中加入BR（4mL，78mmol）。 将混合物在0℃下搅拌1小时，然后温热至室温，将混合物在室温下搅拌1小时。 将得到的混合物用二氯甲烷（500mL）稀释，用饱和NaHSO 3（3×100mL）和盐水（200mL）洗涤，用无水硫酸钠干燥，过滤并浓缩，得到标题化合物（16.6g，100％），为 灰白色固体，用于下一步。
参考文献：
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合成路线 2（2. 合成：17332-11-5）
产率：88%
合成条件：With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide In acetonitrile at 20℃; Irradiation
实验步骤：一般步骤：向装有磁力搅拌棒的10mL圆底烧瓶中加入酚类或烯烃（0.1mmol），CBr4（33mg，0.1mmol），无水CH3CN（1mL）和Ru（bpy）3Cl2（3.8mg） ，0.005毫摩尔）。 在室温下将混合物用蓝色LED（1W）照射，通入空气直至原料完全消失（通过TLC监测）。 反应完成后，将溶剂真空浓缩。 通过快速柱色谱法纯化残余物，得到最终产物。
参考文献：
- [1] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 622 - 627
合成路线 3（3. 合成：17332-11-5）
产率：85%
合成条件：With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide In acetonitrile at 20℃; Irradiation
实验步骤：一般步骤：向装有磁力搅拌棒的10mL圆底烧瓶中加入酚类或烯烃（0.1mmol），CBr4（33mg，0.1mmol），无水CH3CN（1mL）和Ru（bpy）3Cl2（3.8mg） ，0.005毫摩尔）。 在室温下将混合物用蓝色LED（1W）照射，通入空气直至原料完全消失（通过TLC监测）。 反应完成后，将溶剂真空浓缩。 通过快速柱色谱法纯化残余物，得到最终产物。
参考文献：
- [1] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 622 - 627
