88847-89-6 8-羟基-2'-脱氧鸟苷

名称和标识

中文名: 8-羟基-2'-脱氧鸟苷
英文名: 8-OXO-2'-DEOXYGUANOSINE
CAS号: 88847-89-6
分子式: C10H13N5O5
分子量: 283.24
中文别名: 2-氨基-9-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-3H-嘌呤-6,8(7H,9H)-二酮; 8-OH-脱氧鸟嘌呤; 8-羟基-2'-脱氧鸟嘌呤; 2'-脱氧-7,8-二氢-8-氧代鸟苷; 8-羟基脱氧鸟苷; 2'-脱氧-8-氧代鸟嘌呤; 8-氧-2'-脱氧鸟苷; 核酸氧化8-羟基脱氧鸟苷
英文别名: 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine; 8-Oxodeoxyguanosine; 8-hydroxy-2'-deoxyguanosine; 2'-deoxy-7,8-dihydro-8-oxo-guanosine; 2'-Deoxy-8-oxo-7,8-dihydroguanosine; 8-oxo-7,8-dihydro-2'-deoxiguanosine; 8-oxo-7-hydrodeoxyguanosine; 8-hydroxydeoxyguanosine; 8-Hydroxy-2’-deoxyguanosine; 2'-Deoxy-7,8-dihydro-8-oxoguanosine

安全说明

WGK Germany:3 RTECS号:MF8782675 海关编码:29349990 存储类别:11 - 可燃固体

用途与制备

生物活性 8-Hydroxy-2'-deoxyguanosine 是氧化应激和致癌反应的关键生物标志物。
靶点 Human Endogenous Metabolite
体外研究 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.

医药

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