1,4-二溴-2,5-双(溴甲基)苯用作有机、医药中间体。
医药; 农药
合成路线 1（1. 合成：35335-16-1）
产率：31.6%
合成条件：With N-Bromosuccinimide; nitrogen; dibenzoyl peroxide In tetrachloromethane; ethanol
实验步骤：实施例14化合物251的制备将2,5-二溴 - 对二甲苯（26.4g，0.1mol）和NBS（39g，0.22mol）悬浮在四氯化碳（300ml）中，加入过氧化苯甲酰（0.6g）。 将氮气流鼓泡通过反应5分钟。 将反应用100℃的油浴加热2小时。 加入乙醇（200ml）并过滤反应。 剩余的固体用乙醇（50ml）洗涤并真空干燥，得到1,4-二溴-2,5-双 - 溴甲基 - 苯，为白色固体（13.36g，31.6％）。 1H-NMR（500MHz，CDCl3）：δ7.68（s，2H），4.50（s，4H）。
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